A non-enzymatic glucose sensor enabled by bioelectronic pH control

Summary

Continuous glucose monitoring from sweat and tears can improve the quality of life of diabetic patients
and provide data for more accurate diagnosis and treatment. Current continuous glucose sensors use
enzymes with a one-to-two week lifespan, which forces periodic replacement. Metal oxide sensors
are an alternative to enzymatic sensors with a longer lifetime. However, metal oxide sensors do not
operate in sweat and tears because they function at high pH (pH> 10), and sweat and tears are neutral
(pH= 7). Here, we introduce a non-enzymatic metal oxide glucose sensorthatfunctions in neutral fuids
by electronically inducing a reversible and localized pH change. We demonstrate glucose monitoring
at physiologically relevantlevels in neutral fuids mimicking sweat, and wireless communication with a
personal computer via an integrated circuit board.

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Publication

A non-enzymatic glucose sensor enabled by bioelectronic pH control. Strakosas, X., Selberg, J., Pansodtee, P., Yonas, N., Manapongpun, P., Teodorescu, M., & Rolandi, M. Scientific reports, 9(1), 10844.